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BOTHELL, Wash., March 20, 2022 (GLOBE NEWSWIRE) — Athira Pharma, Inc. ATHA, a late clinical-stage biopharmaceutical company focused on developing small molecules to restore neuronal health and slow neurodegeneration, today announced that study overview and baseline data from ACT-AD, a fully enrolled Phase 2 clinical trial of Athira’s lead development candidate, fosgonimeton (ATH-1017) in study participants with mild-to-moderate Alzheimer’s disease (AD), were presented in an oral presentation at the International Conference on Alzheimer’s and Parkinson’s Disease and Related Neurological Diseases (AD/PD™ 2022) taking place in Barcelona, Spain, and virtually from March 15-20, 2022.
Of the 77 study participants enrolled in the randomized, double-blind, placebo-controlled trial, the mean age is 71.4 years, with 50.6% female and 49.4% male, and an average baseline MMSE of 19.3. This includes 31 patients with mild Alzheimer’s disease (mean baseline MMSE 21.8) and 46 with moderate Alzheimer’s disease (mean baseline MMSE 17.5). The average frequency of the APOe4 gene among all study participants is in line with the general AD population. The preliminary baseline ERP P300 latency is 381 milliseconds. At a preliminary data cut, 57 patients completed the study and approximately 14 percent discontinued prior to study completion.
“The baseline data demonstrate that the patient population enrolled in the ACT-AD study are representative of the mild-to-moderate Alzheimer’s population and appropriate to evaluate the effectiveness of fosgonimeton on ERP P300 latency, a functional, objective measure of working memory processing speed,” said Hans Moebius, M.D., Ph.D., Chief Medical Officer at Athira. “Change in ERP P300 latency may be indicative of enhanced synaptic function and potentially improving Alzheimer’s disease. The topline data readout from ACT-AD, targeted for the second quarter of this year, will be informative for the future analysis of our currently enrolling,…
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