Evelo Biosciences Presents Late-Breaking Oral Abstract on Data from Phase 2 Tria… – Press Release

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CAMBRIDGE, Mass., March 26, 2022 (GLOBE NEWSWIRE) — Evelo Biosciences, Inc. EVLO, a clinical stage biotechnology company developing SINTAX™ medicines as a new modality of orally delivered treatments for inflammatory disease, today presented a late-breaking oral abstract on data from a Phase 2 trial of EDP1815 in psoriasis at the 2022 American Academy of Dermatology (AAD) Annual Meeting, being held March 25-29 in Boston, Massachusetts.

“We are proud to join the dermatology community at AAD to share the latest data from the clinical development of EDP1815 in psoriasis. The data being shared demonstrate the potential of Evelo’s SINTAX platform, and support progression towards registration trials for EDP1815,” said Douglas Maslin, M.Phil, M.B. B.Chir, Dermatology and Pharmacology Physician at Addenbrooke’s Hospital and Clinical Lead, Late Stage Development of Evelo. “These data, combined with positive feedback from patients and physicians, as highlighted by our recent KOL event, suggest the potential profile of EDP1815 as a safe, effective, oral, and well-tolerated therapy for psoriasis, which could address a significant unmet need for patients across all stages of disease.”

Late-Breaking Oral Presentation at AAD 2022

  • A phase 2 study investigating the effect of EDP1815, an orally-delivered, anti-inflammatory, gut-restricted commensal microbe in the treatment of mild and moderate plaque psoriasis, D. Maslin, Y. Mihaylov, D. Macaro, N. Carpenter, G. Mehraei, M. Bodmer, J. Zung, M. Plinio, D. McHale, B. Ehst
    • EDP1815-201 was a Phase 2 clinical trial evaluating EDP1815 versus placebo for the treatment of mild and moderate psoriasis, comprised of a Part A, where patients received either EDP1815 or placebo for 16 weeks, and a Part B, where patients were followed for up to 24 weeks after they had stopped receiving EDP1815 or placebo.
    • EDP1815 was well tolerated with safety data comparable to placebo: no drug-related serious adverse events, and no meaningful difference in…

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